January 7, 2020

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses through modulation of immunodominance

Cirelli KM et al.,

A comprehensive study in non-human primates that utilizes immunological, bioinformatic and high-resolution imaging approaches to elucidate the mechanism by which sustained delivery of an Env-based HIV vaccine over two weeks leads to 20-fold higher neutralizing antibody generation when compared with traditional bolus delivery.